The Complete Peptide Protocol: How to Stack for Maximum Results

The most powerful results in wellness don't come from a single solution — they come from understanding how the body's systems interact and addressing multiple pathways simultaneously. Peptide stacking is the science of combining complementary compounds to create synergistic effects that each individual peptide couldn't achieve alone. At Rejuven, we've designed three foundational protocols specifically for the goals we hear most often from our community.

The Transformation Stack: Weight + Skin + Energy

The most comprehensive protocol combines Retatrutide (for triple-receptor metabolic support), GHK-Cu (for skin rejuvenation and collagen restoration), and NAD+ (for cellular energy and DNA repair). Retatrutide handles the metabolic transformation. GHK-Cu ensures that as the body reshapes, the skin firms, tightens, and glows rather than sagging. NAD+ powers the cellular repair processes that make both compounds more effective. Women who run this stack consistently describe it as a complete body and skin overhaul.

The Metabolic Stack: Maximum Fat Loss

For those whose primary goal is aggressive fat loss and metabolic restoration, the combination of Retatrutide with MOTS-C creates a dual-mechanism metabolic assault that is difficult to match. Retatrutide manages appetite and activates fat oxidation via its tri-receptor mechanism. MOTS-C activates AMPK to drive fat burning at the cellular level and improves insulin sensitivity simultaneously. Together, these two compounds address both the hormonal and mitochondrial dimensions of weight resistance.

The Anti-Aging Skin Stack

For those whose primary focus is reversing skin aging — particularly the collagen loss and skin thinning associated with hormonal changes — GHK-Cu combined with BPC-157 and NAD+ creates a powerful regenerative trio. GHK-Cu drives collagen remodeling. BPC-157 reduces systemic inflammation that accelerates skin aging and supports gut health (which directly affects skin clarity). NAD+ restores the cellular energy required for all repair processes. Used with the GHK-Cu Facial Cream for topical support, this protocol represents the most complete anti-aging approach we offer.