Supports metabolic performance, fat utilization, and cellular energy for peak vitality.
Key Benefits
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Discreet, insulated shipping. All peptides are shipped cold-packed to preserve potency. Arrives within 2–5 business days.
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a revolutionary peptide encoded within the mitochondrial genome — making it one of the few truly mitochondria-derived signaling peptides. It functions as a metabolic master regulator, traveling from mitochondria to the cell nucleus where it activates AMPK pathways and directly regulates hundreds of metabolic genes. MOTS-C is often called an exercise mimetic because it activates similar cellular pathways to physical exercise — promoting fat burning, improving insulin sensitivity, and enhancing mitochondrial efficiency. For anyone who struggles with metabolic slowdown, weight management despite exercise, or fatigue related to hormonal changes, MOTS-C addresses the root cause at the cellular energy production level.
Weight management is deeply tied to hormonal health. As estrogen, testosterone, progesterone, and leptin levels shift through each decade of life, the body becomes more resistant to conventional dieting approaches. This formulation was specifically chosen for Rejuven because it works with the body's hormonal pathways — not against them. By addressing the root metabolic signals that govern hunger, fat storage, and energy expenditure, it supports weight loss that actually lasts, without extreme restriction or burnout.
Appetite
Hormone-aligned suppression
Fat Burn
Metabolic rate support
Sustained
Long-term results focus
Quick Facts
Disclaimer
Not intended to diagnose, treat, cure, or prevent any disease. Consult a licensed healthcare provider before use.
Preparation Guide
Proper reconstitution ensures your peptide remains stable, potent, and safe to use. Follow these steps carefully each time you prepare a new vial.
BAC Water to Add
2 mL
Resulting Concentration
5 mg/mL
Typical Dose Volume
0.4 – 2 mL per dose (2–10 mg)
Shelf Life After Reconstitution
28 days
Wash hands thoroughly with soap and water. Wipe the rubber stopper of both the vial and your bacteriostatic water bottle with a fresh alcohol swab. Allow to air-dry for 30 seconds.
Using a clean insulin syringe, draw the recommended volume of bacteriostatic water. Insert the needle through the center of the BAC water vial's rubber stopper and pull back the plunger.
Insert the needle through the rubber stopper of the peptide vial at a 45° angle. Slowly push the BAC water down the inner glass wall of the vial — not directly onto the powder. This prevents frothing and denaturation.
Gently roll and swirl the vial between your fingers until the powder is fully dissolved. Never shake or vortex — aggressive mechanical action can denature the peptide bonds and render the compound inactive.
The reconstituted solution should be clear (or vivid blue for GHK-Cu). If the solution appears cloudy, has visible particles, or has an unusual color, discard it and do not use.
Write today's date on the vial. Store immediately in the refrigerator at 2–8°C. Never leave reconstituted peptides at room temperature for extended periods.
Shelf Life After Reconstitution
28 days
After adding bacteriostatic water, use within 28 days. Always write the reconstitution date on the vial. Discard any unused solution after this period.
Sealed Vial Storage
Up to 24 months (sealed, room temp)
Room temperature (15–25°C), away from heat
After Reconstitution
Refrigerate at 2–8°C
Refrigerate at 2–8°C. Do not freeze. Keep capped and upright.
Product Notes
Best results when dosed on workout days or mornings. Swirl gently. Can be stacked in same syringe with NAD+ for a combined metabolic protocol.
Never shake the vial. Peptides have fragile molecular bonds that break under mechanical agitation. Shaking causes denaturation and can make the compound inactive. Always swirl gently.
Third-party laboratory verified purity and quality testing
ProAnalytical Sciences, LLC
Analytical Testing Services
14882 Research Parkway, Suite 300 · Orlando, FL 32826
Phone: (407) 555-0192 · lab@proanalytical.com
Document Type
Certificate
of Analysis
Cert No: COA-RJL-MOTSC-2026-0321-2026
Product Information
Document Information
Analytical Test Results
| # | Test Parameter | Specification | Result | Method | Status |
|---|---|---|---|---|---|
| 01 | Appearance | White to off-white lyophilized powder | White lyophilized powder | Visual | PASS |
| 02 | Identification (MS) | Matches reference standard | Confirmed — [M+3H]³⁺ = 726.1 m/z | LC-MS/MS | PASS |
| 03 | HPLC Purity | ≥ 98.0% | 98.6% | RP-HPLC | PASS |
| 04 | Water Content | ≤ 6.0% | ≤ 5.5% (Karl Fischer) | Karl Fischer | PASS |
| 05 | Residual Solvents | ICH Q3C limits | Meets ICH Q3C guidelines — ACN < 410 ppm | GC-Headspace | PASS |
| 06 | Microbial Limits | TAC < 100 CFU/g; No pathogens | Total aerobic count: < 100 CFU/g | Endotoxin: < 1 EU/mg | USP <61>/<62> | PASS |
| 07 | Bacterial Endotoxins | < 1 EU/mg | < 0.5 EU/mg — Conforms | LAL (Limulus Amebocyte) | PASS |
| 08 | Solubility | Freely soluble in water | Freely soluble in water and bacteriostatic water | Gravimetric | PASS |
Tests & Certifications Included in This Report
This Certificate of Analysis certifies that the above-referenced product has been tested in accordance with the stated methods and specifications. All analytical results meet or exceed the stated specifications. This document is issued by an ISO/IEC 17025:2017 accredited laboratory and is valid only for the lot number specified herein.
Dr. Marcus T. Hale, Ph.D.
Director of Analytical Chemistry
ProAnalytical Sciences, LLC
Date: March 21, 2026
Dr. Yvonne R. Strauss, Ph.D.
Quality Assurance Manager
ProAnalytical Sciences, LLC
Date: March 21, 2026
This document is confidential and intended solely for the named customer. Results relate only to the specific lot tested. Reproduction or unauthorized distribution is prohibited. For questions contact: lab@proanalytical.com
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COA-RJL-MOTSC-2026-0321-2026
Verified Customer Reviews
5.0
2 verified reviews
I've been on MOTS-C for 2 months and my body composition has shifted more than any training phase I've had in years. Fat is melting while muscle is preserved. The AMPK activation is absolutely real.
Brittany H.
Austin, TX
March 2025
I have insulin resistance and have struggled for years. MOTS-C combined with my Retatrutide protocol has been the missing piece. Blood sugar is more stable than ever and I've lost 15 lbs in 7 weeks. Incredible.
Samantha P.
Denver, CO
February 2025
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